George H.W. Bush volunteers to go to woar and do his duty. The returning hero is reunited with his sweetheart Barbara and they give birth to their first child, the future President George W. Bush. Tragedy strikes when they lose their daughter Robin. Prescott Bush heads for the Senate while George H.W. begins his political journey from Texas to Washington.

Blinded by loyalty to his president and ignoring the advice of his family, George H.W. Bush is betrayed by Richard Nixon. His children start to follow in his footsteps, a young Jeb gets married to Columba while George W. falls in love with Laura. The Bushes rally behind George H.W. as he makes a bid for the White House.

The Bushes have finally made it to the White House but having a father as a president hits Neil Bush hard when scandals strike. George H.W. triumphs against Saddam but the Bush family suffer a bitter election defeat and the loss of their matriarch Dorothy.

George W. and Jeb Bush are two brothers determined to make it to the Governor’s mansion but only one will succeed. Laura Bush fears the consequences of having a second president in the family but she can’t stop her husband becoming “43” who soon faces his greatest ever test as America comes under attack.